Fekrat elyoum7/2/2023 ![]() ![]() Three eyes were no light perception vision and 1Įye had light perception (LP) only vision at 6 months. From pre-endophthalmitis VA to 6 months, patients lost anĪverage of 8 ETDRS lines of vision. VA at 6 months was 20/378 with a mean gain of 10 ETDRS lines across all groups from Mean VA at presentation was 20/4220 and mean Potential cross-reactivity with ceftazidime. Gram-negative coverage because of a penicillin allergy and concern for Changes in logMAR VA and Early Treatment Diabetic RetinopathyĪ One patient received intravitreal amikacin for Snellen VA values were converted to logMAR for 05 was used in all analyses toĭefine statistical significance. Used to identify associations between binary outcomes and continuous predictor Variance testing (for 3 or more sample groups). Categorical variables wereĬompared using χ 2 analysis, and continuous variables were compared usingĮither a 2-tailed t test (for 2 sample groups) or analysis of Statistics were performed using XLSTAT (Addinsoft). Elevated IOP was definedĪs greater than 21 mm Hg and low IOP was defined as less than 9 mm Hg. Involvement on examination) and no other more likely cause. All cases were diagnosed with BRE by anĮxperienced retina specialist based on clinical examination findings consistent withīRE (ie, blebitis with signs and symptoms of endophthalmitis and vitreous Individuals with endophthalmitis presumed to be related to a prior trabeculectomy ![]() Baseline, or pre-endophthalmitis VA, was collectedįrom the most recent clinic visit prior to development of endophthalmitis. Initial treatment choices, microbiologic yield, and corrected visual acuity (VA) at We recordedĭemographic information, ocular comorbidities, presumed etiology of endophthalmitis, Had at least 6 months of follow-up from initial presentation. All participants were aged 18 years or older and We conducted a retrospective review of 133 eyes of 130 consecutive patients that wereĭiagnosed with endophthalmitis at the Duke Eye Center (Durham, North Carolina) from This study aims to evaluate the clinical characteristics, managementĭecisions, and outcomes in cases of BRE at a tertiary academic medical center over a 13 Additional studies are necessary to guide clinical decision-making in eyes 12 However, Busbee and colleagues reported that initial PPV led to better visual outcomes. With intravitreal antibiotics and those that underwent initial PPV both had poor outcomes. Song et al reported that eyes with BRE that underwent vitreous tap The role of PPV in management of BRE and how clinicians can positively influence 10, 11 There is not a similar prospective trial to inform ophthalmologists regarding Is ideal, because the pathogenesis, clinical presentation, and causative organismsĭiffer between individuals with endophthalmitis related to cataract surgery and 9 It is unlikely that extrapolating the EVS’s results for the management of BRE Patients with endophthalmitis after cataract surgery or secondary intraocular lens placement. That assessed the impact of pars plana vitrectomy (PPV) on visual outcomes in The Endophthalmitis Vitrectomy Study (EVS) was a landmark prospective clinical trial 8 However, clinical guidelines for the initial management of BRE are not wellĭefined, with treatment decisions often varying depending on physician Intravitreal antimicrobials and in some cases, vitrectomy surgery. Initial management of BRE involves the prompt administration of broad-spectrum 3 - 7 Eyes that have undergone trabeculectomy may present with endophthalmitis many BRE is relatively uncommon, with a reported incidence of 0.1% to 2%. ![]() Significant intraocular inflammatory event known as bleb-related endophthalmitis However, this surgical filtration pathway may also allowĮxogenous pathogenic bacteria to reach the intraocular space, which can lead to a During this procedure, a channel is created between the anteriorĬhamber of the eye and the subconjunctival space, providing an alternate outflow In certain eyes with glaucoma, trabeculectomy may be necessary to lower intraocular Treatment of endophthalmitis are necessary to save the globe and maximize visual Introduction of pathogenic microbes from the environment. Involving an inflammatory response in the eye that is typically related to the Endophthalmitis is an uncommon sight-threatening complication of intraocular surgery ![]()
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